Anderson was last seen in Moscow, Idaho on April 16, 2010. She has never been heard from again. She was last seen on a Friday, and Anderson's two daughters reported her missing on Monday after she didn't show up for her job at a pathology lab. On April 21, her car, a white 1997 GMC Yukon with the license plate number 1l 93131, was found at a Dynamart station in Lewiston, Idaho, near the Greyhound bus station. Her cellular phone and purse were inside the vehicle.

Prior to her disappearance, Anderson had filed multiple complaints with the police about being harassed and stalked by her an unknown individual. This person had broken her car's back windshield, had slashed her tires, watched her house and sent her disturbing text messages and telephone calls. The incidents began about three months before her disappearance. She was afraid for her life.

Anderson's estranged husband, Charles A. Capone, was arrested on a weapons charge in May 2010. He has a long criminal history dating back to 1985 and a history of violent behavior towards women. As a convicted felon, he is prohibited from having guns. Anderson's daughter stated Capone was an abusive, controlling husband and that Anderson had filed filed harassment charges against him. They were married for only three months before Anderson filed for divorce in January 2010. After Capone's arrest, he was named as a person of interest in his wife's disappearance. He hasn't faced charges in connection with it, however. He later pleaded guilty to unlawful possession of a firearm.

Anderson lived in the 2200 block of Main in Clarkston, Washington at the time of her disappearance, and some agencies stated she went missing from there. Clarkston police are investigating her case, which remains unsolved. Foul play is suspected.