Andrews was last seen at 11:15 p.m. on November 16, 1990, when she left her nursing job at the Methodist Manor Home in Seaford, Delaware. She has never been heard from again. Her 1985 Mercury Cougar was located at 2:00 p.m. the day after her disappearance, parked behind a business on Route 13. Andrews's purse and other belongings were scattered on the ground near the driver's side door, and her keys were on the trunk lid.

Authorities believe foul play was involved in Andrews's case. She has two daughters. She divorced in 1982, but was reconciling with her ex-husband at the time of her disappearance. He has been named as a person of interest in her disappearance. Her case remains unsolved.