Brantley was last seen in Cleveland, Tennessee sometime in late May or early June 2009. She lived with her husband of nine years and three dogs in the Benwood subdivision of Cleveland at the time of her disappearance. Her parents are deceased and she has no children. A friend reported Brantley missing in November 2009, after months without contact. When questioned by police, her husband stated she had simply left him and they planned to get a divorce. Investigators searched her home for evidence, but didn't find anything.

Brantley previously worked for Lee University. She enjoys hiking and other outdoor pursuits, and she is an award-winning writer. Prior to her disappearance, she enjoyed spending time in a camper she owned in Townsend, Tennessee. Police have been unable to locate Brantley's camper and would like to examine it for evidence. Her case remains unsolved.