Calvo was last seen by family members on the morning of October 6, 2005 in New Haven, Connecticut. She was homeless at the time and occasionally lived on the streets, but on the day of her disappearance she said she planned to move back in with her parents and enter drug treatment. Calvo had lost custody of her children as the result of her drug addiction and wanted to get them back.

Calvo's loved ones have not heard from her since her disappearance, though there have been possible sightings of her in the local area since her disappearance. In 2005 she frequented the Grand Avenue and Murray Place areas of New Haven.

Calvo knew Evelyn Frisco, another New Haven woman who vanished the year before she did. There's no indication that their cases are connected, however. The circumstances surrounding Calvo's disappearance are unclear and her case remains unsolved.