Chandler was last seen at her home in the 5500 block of Highway 34 north in Wolfe City, Texas at 5:00 p.m. on September 23, 2007. She has never been heard from again. When she disappeared she left her house unlocked with windows open, and also left behind all her personal belongings, including her purse and cigarettes. Dogs tracked Chandler's scent south along the highway for five miles from before they lost the trail. She may have been picked up by a passing motorist.

Foul play is possible in Chandler's case, as it is uncharacteristic of her to disappear completely and without warning. Some of her associates were involved with drugs, but it is unclear whether drugs were a factor in her case. She had been living in her house for twenty years prior to her disappearance. Her case remains unsolved.