Crume was last seen in Orlando, Florida at 8:30 p.m. on June 2, 2004. He was driving his white 2004 Ford F-150 pickup truck with Florida license plates numbered E41ZVF. He was supposed to meet his wife at a Home Depot store at Hiawassee and Colonial Drive so they could pick up a freezer, but he never arrived at the store and has never been heard from again.

At 12:30 a.m. on June 4, Crume's truck was found abandoned and burning in Fort Myers, Florida. Witnesses saw an unidentified man getting out of the vehicle, but by the time emergency personnel arrived the scene, the man was gone. There was no indication of Crume's whereabouts at the scene. Investigators are not sure whether the fire was intentionally set or whether the vehicle's catalytic converter overheated and started the fire.

Crume is well-known in the Orlando area; for thirty years he was the host of a gospel show on WOKB radio. His case remains unsolved.