Delfi-Feliciano was last seen in the Barrio Jauca neighborhood of her hometown of Santa Isabel, Puerto Rico, about forty-five minutes southwest of San Juan, on May 2, 1992. She was visiting her grandparents' residence at the time and was apparently abducted while playing in a neighbor's front yard at approximately 8:00 p.m. Delfi-Feliciano is described as an intelligent, playful and affectionate child who loves riding her bicycle and playing outdoors.

It has been established that Delfi-Feliciano was in the company of a family acquaintance sometime after her initial disappearance. The individual has since returned to Puerto Rico, but Delfi-Feliciano has not been located. It is believed that the child may be in a Puerto Rican community in Massachusetts, New York or Florida. Her family has ties to those regions of the country. She may also be in the Dominican Republic.

Delfi-Feliciano's case remains unsolved. In the years since her disappearance, her case has been reclassified from a non-family abduction to endangered missing, and then to a family abduction case.