Fischer was last seen at approximately 4:00 p.m. on December 18, 2006 at her boyfriend's residence in the vicinity of the 200 block of east Blackhawk Avenue in Prairie du Chien, Wisconsin. She and her boyfriend apparently had an argument and he told her he wanted to end the relationship and demanded that she leave his apartment. She has never been heard from again. At the time of her disappearance, she did not have a job, a vehicle, a driver's license or a permanent address. She relied on friends and family for housing and transportation, and moved frequently, keeping her belongings in a tote bag and a small duffel bag.

Fischer's parents notified authorities of her disappearance on December 28. They became concerned because she had not contacted them over the Christmas holidays. Her disappearance is described as completely out of character and there are concerns for her safety; her parents do not believe she would have left of her own accord. They describe her as a naive, childlike, immature and easily suggestible young woman.

Fischer has two young children who were in foster care at the time of her disappearance. She went missing once before, in 2004, when she abruptly moved to Iowa to be with the man who fathered her first child. However, in that instance she told friends of her travel plans, and she called her mother a short time after arriving in Iowa. Fischer has not had contact with any of her loved ones since her 2006 disappearance, and had not mentioned a wish to leave the area. Authorities believe she was murdered. As no one she knows is considered a suspect in her case, investigators think she could have been the victim of a random attacker. Her case remains unsolved.