Flores was last seen in Cordell, Oklahoma on January 26, 2007. She was at the south Glenn Street house of her estranged boyfriend, Ronny Denny Jr., at the time. She called her sister-in-law at 8:00 a.m. to say she was on her way to pick up her three children. She never arrived and has never been heard from again.

Flores left her car behind at Denny's home with her purse, cellular phone and makeup inside it. He was subsequently arrested on drug and weapons charges and received a suspended sentence. He has not faced any charges in connection with Flores's case, but he is considered to be a person of interest in her disappearance. He is the father of her youngest child. About six months before she went missing, Flores asked for an order of protection against Denny. She stated he had threatened to shoot her in the face. A week later, however, she asked for the order to be dismissed.

Jason Canterberry, a childhood friend of Denny, stated Denny told him he had murdered Flores. Denny allegedly stated he and Flores got into an argument and he shot her twice with a rifle, and she died in his arms. Supposedly, another man was present at the time of the shooting and this individual called his brother to help clean up the crime scene. Canterberry testified about Denny's alleged confession before a grand jury. Denny denied having ever made such a confession and characterized Canterberry as a drug addict. He maintains his innocence in Flores's disappearance.

As there have been no sightings of Flores since she was reported missing, she is believed to be deceased. Foul play is suspected in her case, which remains unsolved.