Griffin's three children arrived home from school on October 24, 1975 and found the door locked and Griffin missing, along with her car, a gold 1975 Monte Carlo with a cream-colored top. The children went next door and their neighbor told them that Griffin's husband had left in Griffin's car after putting a large metal trash can in its trunk. He was gone twenty-two hours and came back home covered in mud and acting strangely. He reportedly refused to tell the children where Griffin was. Griffin's husband burned the clothes he had been wearing that day. In the weeks following his wife's disappearance, he acted bizarrely. He cried often and would not sleep in his bedroom; he insisted of sleeping with his two younger children instead. Six months after Griffin's disappearance, her husband committed suicide. Neither he nor anyone else was ever charged in connection with Griffin's case.

Griffin has never been heard from again. She is described as a shy person who rarely left the house. She was allegedly very protective of her children and made all their clothes. She had once been employed by WESCOM in Downer's Grove, Illinois. Griffin's husband was reportedly very abusive and may have been selling narcotics in 1975. Her case remains unsolved.