House was last seen in Lakewood, Colorado on August 16, 1972. She left home and went to the Westland Shopping Center in the 10400 block of west Colfax Avenue to run errands. House later called home and told her daughter she was having car trouble but would be home in half an hour. She has never been heard from again. House's vehicle, a 1967 Oldsmobile Vista, was later found in the Westland Shopping Center parking lot. Witnesses saw the being towed into the lot by a maroon and white Ford Bronco. The Bronco's driver is described as a Caucasian male, 5'11 to 6'0 tall, with dark blond hair that was graying and thin at the top. He has never been identified.

Few details are available in House's case, but she is missing under suspicious circumstances. Foul play is suspected in her disappearance, which remains unsolved.