Lauren was last seen digging in the dirt with other children near her mother's apartment complex in Spring City, Pennsylvania on October 4, 1988. When her mother, Christina O'Donnell, went to check on her later, she was gone. One of Lauren's playmates said he saw her walking towards her home; she was about 100 feet away from her front door at the time. She has never been heard from again.

An extensive search of the area turned up no clues as to Lauren's whereabouts. O'Donnell and the child's father, Michael Jackson, shared custody of her at the time of her disappearance and Michael lived in Philadelphia, Pennsylvania. He had planned to seek full custody of Lauren because he was concerned about the living conditions in her mother's home. Michael describes O'Donnell's neighborhood as a haven for drug activity. O'Donnell herself was arrested on drug charges prior to Lauren's disappearance, and she later admitted she had a substance abuse problem.

Tracker dogs traced Lauren's scent away from her mother's apartment, along Park Road to Route 724 and along there to the Vincent Motel, nearly a mile from the apartment complex, before the dogs lost the trail. Due to the lack of evidence in Lauren's case, investigators believe she was most likely abducted. Her case remains unsolved.