Kyles left her daughter's residence on Southworth Terrace in Kalamazoo, Michigan on September 8, 2007. She said she was going to a friend's house to watch a college football game on television. She was last seen later that day, getting into a black Pontiac Vibe outside her home in the 1200 block of Portage Street. She has never been heard from again. Her relatives reported her missing on September 17.

Kyles's Toyota Camry was found abandoned in the 1900 block of Portage Street on September 19, which is her birthday. The window had been broken, but it is unclear whether anything had been stolen from the vehicle. Kyles's clothes and a suitcase were found in the car's trunk. A photo of the Camry is posted below this case summary.

Since her disappearance, Kyles has not had contact with her daughter or granddaughter, which is uncharacteristic of her. She was close to her family and had moved to the Kalamazoo area from Chicago, Illinois in 1999 to be nearer to them. Her food stamps have not been used since she went missing. Her disappearance is considered to be highly suspicious and foul play is possible.

Above: Kyles's Toyota Camry