Lofton was last seen in Tulsa, Oklahoma on July 10, 2007. At the time of her disappearance, she was living with her boyfriend in an apartment in the 10200 block of east 23rd Street. She had graduated with honors from the Dallas School for Science and Engineering in Dallas, Texas in 2005 and enrolled at the Spartan College of Aeronautics and Technology; she majored in aeronautical engineering and dreamed of becoming a pilot.

Lofton's vehicle and belongings were left behind at her residence. Her disappearance remains unsolved.