Luzio was last seen at approximately 4:00 a.m. on July 4, 2005, leaving a party at an acquaintance's residence in the vicinity of the 4000 block of Bayhill Drive, near Rutherford Road, in Powell, Ohio. The location is less than a mile from Luzio's parents' home. He has never been heard from again. His silver four-door 2004 Honda Civic with Ohio license plates numbered DCA-5615 or DCS-5615 is also missing. There is a Fraternal Order of Police emblem on the rear license plate and a "Bush/Cheney" sticker on the rear window of the car.

Other guests at the party assumed Luzio was on his way back to his own apartment, although he had given the key to a friend. He may have been intoxicated when he left the gathering. Later that day, Luzio was supposed to work third shift at his security job at The Limited Brands Inc. His parents were notified when he failed to arrive at work; after searching for him without result, they reported him as a missing person.

Luzio's father is a sergeant with the Columbus, Ohio police department. Authorities do not believe Luzio's disappearance has anything to do with his father's occupation, however. Luzio had limited money at the time of his disappearance, and his bank account and cellular phone have not been used since he went missing. He had worked with The Limited for six years prior to his disappearance, and he has no history of illness, nor was he showing any signs of drug or alcohol abuse at the time he disappeared. Authorities are concerned for his safety and believe he may have met with harm; however, his case remains unsolved.