Main disappeared from her home in the 19600 block of Pemberville Road in Pemberville, Ohio on August 17, 2006. Her husband last saw her at 2:30 a.m. When he woke up at 6:30 a.m., Main was missing and so was his car. At approximately 4:30 p.m., someone called the police department in Oregon, Ohio to report seeing a tan Blazer broken down at the intersection of Bay Shore Road and La France Street in Oregon. The witness stated there was a blonde woman inside the vehicle and she was "acting strange." The woman refused assistance, got out of the vehicle and walked east on Bayshore Road.

When police responded to the call, the woman could not be located. The Blazer was Main's husband's, and he had it towed back to his residence. Main has never been heard from again. She left her purse and cellular phone behind. There was no indication of forced entry to her home.

Prior to her disappearance, Main frequented the LaGrange Street area of Toledo, Ohio. She had run away before, but never for this long, and she always kept in touch with her family. Her case remains unsolved.