McFadyen was last seen at her home in northwest Austin, Texas on February 22, 2011. She was packing to move at the time of her disappearance, and also planning for an upcoming trip to England. She has never been heard from again. In April, her car was found abandoned a few blocks from her house.

Garry Dolbow, McFayden's ex-boyfriend, is the last person known to have seen her and is considered a person of interest in her disappearance. Dolbow, who lives in Fresno, California, travels a great deal for business purposes. The police have interviewed him several times about McFadyen and he once came to Austin specifically to talk to them.

McFadyen's loved ones stated she was behaving normally before she went missing and it's uncharacteristic of her not to contact them. Little information is available in her case, but foul play is suspected.