Mosley was last seen at approximately 2:45 a.m. on April 17, 1995. She visited two nightclubs in Pikesville, Maryland, then a a friend dropped her off at High Falcon Road and Pittston Circle in Reistertown, Maryland, near another friend's apartment. Mosley resided in the 100 block of Westminster Pike in Reistertown at the time of her disappearance.

Mosley was reported missing at 10:00 p.m. that day when her purse was found on Pittston Circle. The purse had nothing missing from it. Mosley has never been heard from again. Her loved ones say it is uncharacteristic of her to leave without warning, and she is not believed to have been carrying any money with her at the time of her disappearance. Mosley was declared legally dead in 2000; the court determined she had probably been murdered. Foul play is suspected in her case, which remains unsolved.