Lisa's family moved to Rockingham County, South Carolina in 1991. She dropped out of high school in 1996 and married Ricky Dean Neugent. Ricky was convicted of assaulting Lisa three times during their marriage. She met Frank Lloyd Isley Jr. at Times Turn Around Food Store in Stokesdale, South Carolina in May 1997. Isley's photos and 1999 vital statistics are posted below this case summary. According to her family, Lisa was looking to escape from her abusive marriage to Ricky and moved in with Isley shortly after meeting him. Lisa and Isley resided in his hometown of Conway, South Carolina.

Lisa was employed with a courier service in Conway, but began working at Isley's Painting and Odd Jobs, Isley's family's business and his place of employment. Lisa's loved ones said that Isley was possessive of Lisa and wanted her to be with him at all times. Lisa and Isley were married in July 1997, but she was not divorced from Ricky and the marriage was not legal.

Lisa and Isley were apparently happy together for the next two years. Her parents visited with the couple during the first weekend in September 1999. Isley did not return home during the final night of the vacation; according to Lisa's mother, her daughter told her Isley was using drugs. Lisa's parents pleaded with her to return to her family's residence and she agreed. Isley began calling her on September 8, the day after arriving home with her family. He arrived at her parents' house and said he rented a nearby hotel room; Isley said he would bring Lisa back the following morning after they discussed their relationship.

Isley drove to the Sea Mist Resort in Cherry Grove Beach, South Carolina instead. The resort is located near Myrtle Beach. Lisa called a friend and asked her to drive out to the hotel, then called her parents at her friend's suggestion. Lisa told her mother that she would be returning to their home on September 20 after she and Isley finished a home repair project in Cherry Grove Beach. She has never been heard from again.

Isley phoned one of Lisa's friends on September 12 and claimed that Lisa left the resort in the early morning hours of September 9, three days earlier. Isley said that Lisa took their dog and also took $1,200 from his pockets as he slept. Her friend requested Lisa's parents' phone number and said Isley refused, telling the friend she had "no reason for it now."

Lisa's parents attempted to call and page their daughter for over one week. They traveled to Cherry Grove Beach in an effort to speak to authorities and attempt to locate their daughter. Hurricane Floyd hit the South Carolina coast during this time and law enforcement officials were overwhelmed with its destruction. Authorities checked the Conway residence Isley and Lisa shared several weeks after she disappeared. Their landlady said that Isley had moved out of the home weeks before. There was no sign of Lisa at the house, which had reportedly been ransacked.

South Carolina investigators learned Isley had been arrested on narcotics and burglary charges in Thomasville, Georgia in October 1999, one month after Lisa's disappearance. Isley's court appearance was scheduled for February 21, 2000 in Georgia, but he never arrived. Authorities are searching for Isley in an effort to question him regarding Lisa's disappearance. There have been no arrests in her case and he is not considered a suspect. Isley is also wanted failure to pay support in South Carolina, in addition to the charges in Georgia. He may be driving a blue 1989 GMC pickup truck with an attached toolbox.

Lisa's disappearance remains unsolved. Authorities consider her case as that of a missing person, as no evidence of foul play has been discovered.