Procopio left work at QVC, where she was an accounts receivable specialist, in West Chester, Pennsylvania at approximately 5:10 p.m. on September 24, 1999. She told her coworkers she was planning to meet someone after work. She was last seen near the Newton Shopping Center in the vicinity of Route 3 and Route 252 at approximately 7:00 p.m. that day. She never arrived home and has never been heard from again. She was reported missing by her sister on October 5.

Procopio's vehicle, a red 1990 Pontiac Sunbird coupe, was located behind Chick's Tavern in the 200 block of Front Street in Bridgeport, Pennsylvania on October 7, two weeks after Procopio disappeared. It was legally parked, the anti-theft device was in place, and the driver's seat was adjusted to Procopio's height. It had been wiped completely clean of fingerprints.

After Procopio's disappearance, authorities discovered that she had been secretly working as a dominatrix, using the name Mistress Maria. She had her own 900 number and hundreds of clients. Her family and friends knew nothing about it. It is unclear what, if anything, the dominatrix work has to do with her disappearance. Procopio's loved ones believe her boyfriend physically abused her prior to her disappearance, but this has not been confirmed. The boyfriend maintains his innocence in her case. He was found guilty of welfare fraud after Procopio vanished and sentenced to prison. Procopio was the one who had tipped authorities off to his criminal activities, just days before she disappeared.

Procopio resided in the 2400 block of south Opal Street in Philadelphia at the time of her disappearance, and frequented West Chester and Newtown Square, Pennsylvania. Procopio's case remains unsolved. She is considered to be endangered; foul play is suspected in her disappearance.

Above: Procopio's ring