Annette was last seen in Pembroke Pines, Florida on January 26, 2000. Her common-law husband, Naraine "Cyril" Ramsammy, did not report her as a missing person for two months. He had various explanations as to Annette's disappearance, claiming she gone to Trinidad to have an abortion, she was hospitalized after trying to commit suicide by jumping off a cruise ship, and she had left their home of her own accord. Annette left behind a young son. Five months after her disappearance, Annette's mother in Guyana received a typewritten letter supposedly from her. The letter stated she had wronged Ramsammy. Its return address was from the same zip code as Ramsammy's home.

Annette was previously married to Ramsammy's brother, Sahadeo Kumar, and had a child by Kumar before moving to the United States. She and Ramsammy called each other husband and wife but were never legally married. Ramsammy paid a transsexual dancer, Darren Rabino (now known as April Rabino), $10,000 to marry Annette so she could get a green card and stay in the United States legally. Darren later said Ramsammy treated Annette badly and was controlling. She disappeared shortly after Ramsammy found out she was having an affair and was pregnant by her lover, a neighbor. Ramsammy threatened to kill both of them when he discovered their relationship. In 2003, Annette and Ramsammy's son stated he saw his father choke his mother until she fell silently to the ground. The boy also claimed the last time he saw Annette was the day after the choking, when she walked out the back door of their home and never returned.

Investigators stated a body located in the Everglades swamp in 2004 may be Annette's. DNA testing to establish the body's identity was inconclusive, but its DNA profile was remarkably similar to Annette's mother and authorities believe she and the victim are biologically related.

Ramsammy was later charged with Annette's murder. At trial, his attorneys argued Annette was still alive and had left on her own. The couple's son testified against his father. Ramsammy was convicted of second-degree murder in March 2008. Foul play is suspected in her case due to the circumstances involved.