Reategui was last seen on November 26, 2000 at her residence at Oakridge Apartments in the 600 block of Rushcreek Street in Houston, Texas. Her neighbors called police to report a domestic disturbance in her apartment on November 27, the following day. When officers arrived at the scene, Reategui was gone.

Police initially believed Reategui had simply returned to her home in Peru. She had been planning on doing so and had told others about the upcoming trip. Several months after her disappearance, however, Reategui's family members in Peru reported her missing and confirmed that she had never arrived there. Subsequent investigation revealed that she never got on her scheduled plane flight.

Investigators contacted Juan Rafael Neciosup, whom Reategui had been living with in November 2000. He moved to the 4400 block of Bramdemere Street afterwards. Neciosup told the police that he had broken up with Reategui and knew nothing of her whereabouts except that she had intended to go back to Peru. Shortly after the interviews and a year to the week since Reategui was last seen, he disappeared as well. He is still missing.

The father of Reategui's daughter, who lives in Peru and has not been publicly identified, is considered a person of interest in Reategui's case. He had previously taken their child without Reategui's knowledge or consent, then sent the child to live with his sister in Houston. Reategui and the man's sister were involved in a custody battle for the girl at the time that she vanished.

Reategui's neighbors say the day after they reported the disturbance in her apartment, they saw two women, both in their fifties, arrive in a white sport utility vehicle (SUV) to clean the apartment where Reategui and Neciosup had been living. The women took several items with them in their vehicle when they left the apartment. It is unclear what, if anything, the women have to do with Reategui's disappearance. They have never been identified.

Both Reategui and Neciosup's cases are unsolved and it is not known if their disappearances are related. Neciosup is wanted by police for further questioning in Reategui's case.