Salisbury was last seen in Burns, Wisconsin at 9:30 p.m. on October 20, 1994. Her live-in boyfriend said she drove away from their rural home after an argument. She has never been heard from again. Her car was found the day after she went missing, parked on Jewett Road, a few miles from home. It had a flat tire. There was no sign of Salisbury at the scene. She left behind her purse, her wallet, her driver's license and her two very young children.

Salisbury's boyfriend has been very uncooperative with the investigation. He maintains his innocence in her disappearance and has custody of their children. Salisbury is described as a devoted mother who would not have abandoned her children. Foul play is suspected in her case, which remains unsolved.