Smith was last seen in Winston-Salem, North Carolina on October 3, 2006. His girlfriend went out in the middle of the night to get food, and when she returned he was gone. He changed his shirt and left his girlfriend's house on Booker Street, driving his bright blue/turquoise 1993 Pontiac Grand Am with the North Carolina license plate number NYB3645, and has never been heard from again. There were reported sightings of him in the local area after his disappearance, but none of these were confirmed. His vehicle, which contained several extra changes of clothes, was never located.

Smith maintained daily contact with his loved ones prior to his disappearance, and he had promised his mother he'd visit her house on October 4, but none of his family and friends have heard from him since he went missing. He graduated from Parkland High School and was attending Forsyth Technical Community College at the time of his disappearance. His case remains unsolved.