Stackhouse left his parents' home in the 100 block of Lynn Circle in Syracuse, New York between 6:00 and 6:30 p.m. on December 2, 2005. He and his friends went to a basketball game at Christian Brothers Academy. When his parents woke up the next morning, their son had still not returned and they reported him as a missing person. He may have been in a green four-door 2003 Hyundai at the time of his disappearance.

In the days following his disappearance, Stackhouse's parents and his girlfriend received several anonymous telephone calls; the caller(s) told them where to find Stackhouse's body. Authorities have no hard evidence that Stackhouse is deceased, but they consider his disappearance to be suspicious. At the time of his disappearance he had two warrants out for his arrest, but investigators do not believe this is why he vanished. Stackhouse left behind a young daughter. His case remains unsolved.