Roxann's husband, William L. Tolson, stated he last saw her at their home in the 700 block of east Mullan Avenue in Post Falls, Idaho on August 14, 2005. He left to run errands and when he returned, she was gone. William did not report her disappearance to police until the following January, four months later. He stated they were having marital problems in 2005 and he believed she may have left of her own accord. He reportedly held a yard sale days after her disappearance and sold many of her possessions, including ceramic collectibles, jewelry boxes, and makeup. He also emptied her bank account.

Authorities believe Roxann is missing under suspicious circumstances, and foul play is suspected in her case. She left behind personal belongings which investigators believe she would have taken if she had left voluntarily. William and his son, Lawrence Ray Tolson, were charged in February 2006 with filling Roxann's prescriptions while she was missing. The charges are unrelated to her disappearance, but investigators stated both William and Lawrence were considered suspects in Roxann's case and William gave inconsistent statements about his wife's disappearance. Her disappearance remains unsolved.