Vasquez was driven from her home in Parkland, Florida and dropped off at a Wal-Mart store the 6000 block of Coral Ridge Drive in Coral Springs, Florida on May 29, 2004. She was planning to buy clothes in anticipation of going away for the weekend. She was carrying a light-colored purse with a shoulder strap and a green computer case containing clothing at the time of her disappearance.

A security camera at Wal-Mart shows Vasquez shopping alone and then leaving the store alone at approximately 7:00 p.m. She was supposed to call a friend to pick her up, but never did. She has never been heard from again.

Foul play is possible in Vasquez's case. She was working as a nanny for a family in the 7700 block of northwest 128th Avenue in Parkland at the time of her disappearance; she had worked there for a year and a half. On January 2, 2005, six months after Vasquez vanished, another Hispanic nanny, this one Peruvian and living in Boca Raton, Florida, vanished. Her body was found three days later; she was the victim of a homicide and her murder remains unsolved. The murdered nanny reportedly bore a strong physical resemblance of Vasquez. Investigators have looked for a connection between the two cases, but have not found one.

Vasquez's case remains unsolved.