Vasquez was last seen at approximately 8:00 p.m. on June 25, 1982 in Alice, Texas, when he left his residence in the 1100 block of Rayo Street to go to a store. He was accompanied by Juan Ramon Suarez, his brother-in-law, at the time of his disappearance, and was riding in an early 1980's white Ford pickup truck with Texas license plates. The truck was later found abandoned at the Alice Police Department.

Later that day, Suarez went to the hospital for treatment of a gunshot wound to the chest. He said he had accidentally shot himself. Later, he changed his story and said Vasquez had shot him. Suarez stated he struck his brother-in-law in the head or neck and left him by the side of the road. Vasquez has never been heard from again.

Suarez has not been charged in Vasquez's disappearance and neither has anyone else, but foul play is suspected in his case. Authorities have searched many locations in Jim Wells County and heard stories about where his body might be buried, but no evidence has been located in his case. It remains unsolved.