Wilkerson was last seen at approximately 11:00 a.m. on July 13, 2004, at her boyfriend's residence near the 2400 block of 118th Street in the south side of Lubbock, Texas. He said she left his home to drive to her own home, then to work at Nothin' Butt Smokes. Wilkerson apparently made it home, but she never arrived at work and has never been heard from again.

Wilkerson's car, a black 1999 Honda Civic coupe, was found parked at her residence after her disappearance. Her house was locked and her car keys and house keys were inside. She also left behind money and all her personal posessions except her tan shoulder strap purse. She never contacted her employer to say she would be absent from work, and never picked up her last paycheck. Neither of her two roommates have heard from her.

Police stated that they were looking for a suspicious vehicle which they believe may have been involved in Wilkerson's disappearance. It is described as a small black truck set low to the ground, with unique smooth hubcaps on the tires and decals in the back window. It may be equipped with hydraulics, and may have tinted windows and out-of-state license plates. The vehicle and its driver have not been located or identified.

Wilkerson's family lives in New Mexico and she had been planning to visit them before she disappeared. She was a sophomore at South Plains College at the time of her disappearance. She was the second young woman to disappear from the Lubbock area in the same time period; sixteen-year-old Joanna Rogers vanished from Lubbock in May 2004. Her remains were found in a local landfill in October 2006. While it is unusual to have two women missing from a comparatively small town at the same time, investigators have found no evidence to suggest that Wilkerson and Rogers's cases are connected.

Authorities believe Wilkerson is missing under suspicious circumstances and may be in danger. They are investigating her disappearance as an abduction. Her case is unsolved.