Williams was last seen at approximately 1:30 a.m. on March 13, 2007, at her workplace, the Eagles Lodge on Highway 14 in Ava, Missouri. She put the night's receipts in the safe, and called her boyfriend to let him know she was come home. She was carrying a brown leather purse and a cellular phone at the time of her disappearance. She never arrived home and has never been heard from again. Williams's vehicle was found in the parking lot the following morning. Nothing was missing from the lodge.

Williams resided in Mansfield, Missouri at the time of her disappearance. Since she went missing there has been no activity on her cellular phone or financial accounts. Her loved ones describe her as a devoted parent who would not have willingly abandoned her four children. Foul play is suspected in her case, which remains unsolved.