Brandy was last seen by her husband, Kenny Wilson, on the morning of June 4, 2002, inside their residence in the 3800 block of west CR 600S in rural Colfax, Indiana. Kenny had been working the night shift so when he got home he went to sleep immediately. When he woke up at 2:00 p.m., Brandy was gone. $420 in cash was also missing from the home, but the couple's vehicles, their wedding rings, and Brandy's purse were all left behind at the residence.

A month after Brandy's disappearance, police announced that they had received a typed letter containing "legitimate leads" in her case. Investigators appealed for the writer to come forward. It is unknown whether the individual ever contacted them.

Authorities at first believed Brandy had simply left Kenny without telling him, but as time passed and she did not contact her employer, family, and friends, they began to believe foul play may have been involved in her disappearance. She left behind two sons, one of whom was an infant at the time she vanished. The Wilsons were reportedly having marital problems at the time Brandy disappeared, so Kenny was given a polygraph by police and passed. He lives in Rensselaer, Indiana with their younger son; the older one is in state custody. Kenny served ten years in prison in the 1980s for robbery with serious bodily injury; he had originally been charged with murder but the charge was reduced as part of a plea agreement.

Brandy's case remains unsolved. Foul play is suspected.